Dinuclear double-stranded metallosupramolecular ruthenium complexes: Potential anticancer drugs

Abstract

Just add a twist: Metallosupramolecular architecture design is used to create anticancer agents with high activities in human breast cancer cell lines. Three isomers, which comprise a nonhelical metallocyclophane, an unsaturated double helicate, and a new type of double helicate, bridge the fields of metallosupramolecular architecture and anticancer drug design (picture: double-helical trans/cis isomer; red Ru, green CI). (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.