Integrin LFA-1 plays an important role in leukocyte trafficking to inflammatory sites as well as the interaction of T cells with antigen-presenting cells. Inhibition of the LFA-1:ICAM-1 interactions is a promising therapeutic approach for alleviating inflammation and autoimmune diseases. This chapter describes cell-free assays to study the LFA-1:ICAM-1 interactions. These assays may be used for screening novel LFA-1 antagonists. © 2011 Springer Science+Business Media, LLC.
CITATION STYLE
Yuki, K. (2011). Cell-free ligand-binding assays for integrin LFA-1. Methods in Molecular Biology, 757, 73–78. https://doi.org/10.1007/978-1-61779-166-6_6
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