The role of regulatory T cells and anti-inflammatory cytokines in psoriasis

Abstract

Psoriasis is a chronic inflammatory disease with a genetic predisposition that can be triggered by environmental factors. Pathogenesis is characterized by activation of the Th1/Th2 axis and abnormalities of the Th17/Treg balance as well as deficiency of antiinflammatory cytokines (IL-10, TGF-β). Regulatory lymphocytes (Treg), which are involved in homeostasis mechanisms, maintain tolerance and prevent autoimmune disorders. Only a few studies have investigated the presence of Treg marker expression and levels of anti-inflammatory cytokines in psoriatic skin and sera of patients with psoriasis. The results of studies are controversial. This article reviews and analyzes what is known about the role of Treg cells and anti-inflammatory cytokines in psoriasis.