Cystoisospora belli Gallbladder Infection in a Liver Transplant Donor

  • Akateh C
  • Arnold C
  • Benissan-Messan D
  • et al.
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Abstract

Introduction . Cystoisospora belli (previously Isospora belli ) is a parasitic protozoan of the human gastrointestinal system. It rarely causes symptoms in immunocompetent hosts but can cause severe diarrhea in immunocompromised patients, with a rate of recurrence and risk of dissemination. Gallbladder infections are however rare. The treatment of choice for symptomatic patients is a 7–10-day course of trimethoprim-sulfamethoxazole. Case . In this case, we report on an incidental finding of Cystoisospora belli organisms in the donor gallbladder following a transplant cholecystectomy. There was no report of symptoms in the donor. The recipient was treated with a course of trimethoprim-sulfamethoxazole, without evidence of cystoisosporiasis. Given the risk of recurrence in immunocompromised hosts, the patient will continue to be monitored for reactivation in the future. Conclusion . Despite advances in transplant protocols and screening, disease transmission from the donor to recipient still occurs in about 0.2% of all organ transplants. With the increased use of organs from drug overdose victims and other high-risk donors, practitioners (including pathologists, hepatologists, and surgeons) must maintain a high index of suspicion for such potentially harmful organisms.

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Akateh, C., Arnold, C. A., Benissan-Messan, D., Michaels, A., & Black, S. M. (2018). Cystoisospora belli Gallbladder Infection in a Liver Transplant Donor. Case Reports in Infectious Diseases, 2018, 1–5. https://doi.org/10.1155/2018/3170238

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