Parkinson’s disease is the second most common neurodegenerative disease without cure. It is characterized by α-synuclein accumulation and aggregation in dopaminergic and other types of neurons. Because α-synuclein accumulation leads to a toxic gain of function, its ectopic expression in Drosophila has been a useful in vivo model for testing modifiers of its toxicity. This chapter describes four assays: The rapid iterative negative geotaxis, rough eye phenotype, quantification of dopaminergic neuronal loss, and measurements of circadian effects.
CITATION STYLE
Szabo, A., & Tofaris, G. K. (2019). Monitoring α-synuclein proteotoxicity in drosophila models. In Methods in Molecular Biology (Vol. 1948, pp. 199–208). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9124-2_15
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