The effect of smoking on myeloid-related protein-8 and myeloid-related protein-14

Abstract

The aim of this study was to determine the myeloid-relatedprotein-8 and myeloid-related protein-14 levels in the gingival crevicularfluid of smoker patients with generalized aggressive periodontitis(SAgP), smoker patients with chronic periodontitis (SCP), smokerpatients with gingivitis (SG-smoker control), non-smoker patients withgeneralized aggressive periodontitis (AgP), non-smoker patients withchronic periodontitis (CP), and non-smoker patients with gingivitis(G-non-smoker control). The periodontal statuses of the patients weredetermined by periodontal clinical measurements and radiographicalevaluations. The levels of myeloid-related protein-8 and myeloid-relatedprotein-14 in the gingival crevicular fluid were assessed usingenzyme-linked immuno sorbent assay. The myeloid-related protein-8and myeloid-related protein-14 levels in the gingival crevicular fluid ofpatients with generalized aggressive periodontitis (non-smoker andsmoker) were found to be statistically higher than patients with chronicperiodontitis (non-smoker and smoker) and patients with gingivitis(non-smoker and smoker). Myeloid-related protein-8 and myeloid-relatedprotein-14 levels of non-smokers were significantly higher thansmokers in all types of periodontitis and gingivitis. The decreasedmyeloid-related protein-8 and myeloid-related protein-14 level couldhave prevented the haemostasis of calcium which plays a significantrole in the migration of neutrophiles. Smoking affects myeloid-relatedprotein-8 and myeloid-related protein-14 levels and may inhibit theantimicrobial efficiency against microorganisms. Due to these reasonssmoker generalized aggressive periodontitis patients need to be treatedin detail and their maintenance durations should be shortened.