A novel neuroprotectant PAN-811 protects neurons from oxidative stress

10Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.

Abstract

Hydrogen peroxide (H2O2), a major non-radical reactive oxygen species (ROS) could elicit intracellular oxidative damage and/or cause extracellular free calcium influx by activating the NMDA receptor or through calcium channels. In the present study, NMDA receptor antagonist MK-801 fully blocked H2O2-induced neuronal cell death, whereas green tea (GT) extract containing-antioxidants only partially suppressed the neurotoxicity of H2O2. These suggest that majority of ROS overproduction is downstream of H2O2-induced calcium influx. A novel neuroprotectant PAN-811 was previously demonstrated to efficiently attenuate ischemic neurotoxicity. PAN-811 hereby fully blocks H 2O2-elicited neuronal cell death with a more advanced neuroprotective profile than that of GT extract. PAN-811 was also shown to protect against CaCl2-elicited neurotoxicity. Efficient protection against oxidative stress-induced neurotoxicity by PAN-811 indicates its potential application in treatment of ROS-mediated neurodegenerative diseases. © 2009 Versita Warsaw and Springer-Verlag Berlin Heidelberg.

References Powered by Scopus

Reactive Oxygen Species and the Central Nervous System

2751Citations
N/AReaders
Get full text

Memantine in moderate-to-severe Alzheimer's disease

1913Citations
N/AReaders
Get full text

Oxidation of ascorbic acid with superoxide anion generated by the xanthine-xanthine oxidase system

496Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Evaluation of antioxidant and cytoprotective activities of Arnica montana L. and Artemisia absinthium L. ethanolic extracts

111Citations
N/AReaders
Get full text

Methanol extracts from Cystoseira tamariscifolia and Cystoseira nodicaulis are able to inhibit cholinesterases and protect a human dopaminergic cell line from hydrogen peroxide-induced cytotoxicity

45Citations
N/AReaders
Get full text

Extracts from Quercus sp. acorns exhibit in vitro neuroprotective features through inhibition of cholinesterase and protection of the human dopaminergic cell line SH-SY5Y from hydrogen peroxide-induced cytotoxicity

44Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Pan, W., Dancik, C. M., Nelson, V. M., Jiang, Z. G., Lebowitz, M. S., & Ghanbari, H. A. (2009). A novel neuroprotectant PAN-811 protects neurons from oxidative stress. Central European Journal of Biology, 4(1), 34–40. https://doi.org/10.2478/s11535-008-0062-1

Readers' Seniority

Tooltip

Professor / Associate Prof. 1

33%

PhD / Post grad / Masters / Doc 1

33%

Researcher 1

33%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 3

75%

Chemistry 1

25%

Save time finding and organizing research with Mendeley

Sign up for free