Visual account of protein investment in cellular functions

240Citations
Citations of this article
420Readers
Mendeley users who have this article in their library.

Abstract

Proteomics techniques generate an avalanche of data and promise to satisfy biologists' long-held desire to measure absolute protein abundances on a genome-wide scale. However, can this knowledge be translated into a clearer picture of how cells invest their protein resources? This article aims to give a broad perspective on the composition of proteomes as gleaned from recent quantitative proteomics studies. We describe proteomaps, an approach for visualizing the composition of proteomes with a focus on protein abundances and functions. In proteomaps, each protein is shown as a polygon-shaped tile, with an area representing protein abundance. Functionally related proteins appear in adjacent regions. General trends in proteomes, such as the dominance of metabolism and protein production, become easily visible. We make interactive visualizations of published proteome datasets accessible at www.proteomaps.net. We suggest that evaluating the way protein resources are allocated by various organisms and cell types in different conditions will sharpen our understanding of how and why cells regulate the composition of their proteomes.

Cite

CITATION STYLE

APA

Liebermeister, W., Noor, E., Flamholz, A., Davidi, D., Bernhardt, J., & Milo, R. (2014). Visual account of protein investment in cellular functions. Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8488–8493. https://doi.org/10.1073/pnas.1314810111

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free