The role of plant metabolites in drug discovery: Current challenges and future perspectives

Abstract

The search for new and novel drugs is never-ending. Despite advances in synthetic chemistry, nature nevertheless remains as an important resource for the drug discovery. For decades, a routine screening of ethnopharmacologically important plants, followed by chromatographic isolation has been the basis of bioprospecting. Recent advances in bioinformatics and in silico screening have further improved our rate and likelihood of finding medicinal metabolites. Multiple classes of naturally occurring plant secondary metabolites, such as polyphenols, terpenoids, and alkaloids have been proven to possess significant medicinal potentials including antioxidant, anti-allergic, anti-inflammatory, anticancer, antihypertensive, and antimicrobial activities. The compounds of interest are often used as a basis or inspiration for semisynthetic drugs with improved pharmacokinetic and pharmacodynamic parameters. However, when a new biologically active compound has been identified, further in vivo testing and clinical trials may not reflect results seen in vitro. As with any promising fields, pitfalls and drawbacks are inevitable; these include poor bioavailability and unknown pharmacodynamics/pharmacokinetics. The drug development is further complicated by other challenges, such as processing, formulation, scaling up, and intellectual property protection. This chapter aims to discuss on the prospects of plant metabolites leading to drug discovery, along with the process and outcomes of testing and the potential pitfalls or challenges faced by researchers and the pharmaceutical industry in this endeavour.