The synthesis of 2,3,5-trisubstituted phenols

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Abstract

Synthetic route to 2,3,5-trisubstituted phenols based on two-step [1+2+3] construction of the phenol backbone from 1-[(trimethylsilyl)methyl]-1H-1,2,3- benzotriazole, aliphatic or arylacetic acid chlorides and chalcones or α,β-unsaturated-γ-diketones was developed. 2,3,5-Trisubstituted phenols 8, 9a-e, 10a-d, 12a-e were successfully synthesized.

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Katritzky, A. R., Ji, Y., Tymoshenko, D. O., Fang, Y., & Hylton, K. G. (2001). The synthesis of 2,3,5-trisubstituted phenols. Arkivoc, 2001(4), 20–28. https://doi.org/10.3998/ark.5550190.0002.404

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