İlk Epizod Major Depresyon Hastalarında Mizaç ve Karakter Özelliklerinin Tedavi Öncesi ve Sonrası Karşılaştırılması

Abstract

Aim: In this study, the association between temperament and character inventory (TCI) subscores and depression scores, and possible changes in temperament dimensions after treatment were explored. Methods: 54 major depressive patients diagnosed according to DSM-IV criteria were enrolled and naturalistic antidepressant treatments were prescribed to the patients. Hamilton Depression Rating Scale (HDRS) and TCI were administered during enrollment and after three months of treatment. Patient group was composed of 31 remitted patients and compared with 75 healthy controls. Results: Comparison of TCI scores of pre-treatment patient group and the control group demonstrated that harm avoidance, self-directedness, and cooperation subscale scores of patients were significantly different from controls (p=0.001, p=0.001 and p=0.001 respectively). The difference between patients and controls persisted even after the treatment. There was no significant difference between pre-treatment and post-treatment TCI outcomes of the patient group (P>0.05). Conclusion: Our findings indicate that harm avoidance, cooperativeness, and self directedness dimensions are not state-related in MDD patients.