Superparamagnetic iron oxide nanoparticles (SPIONs) can be used for the delivery of the anticancer drug Sorafenib, which possesses multikinase inhibitor activity, to specific locations in the body through the application of an external magnetic field. In order to increase the biocompatible and protect the drug, solid lipid NPs (SLN) have been used to contain sorafenib and SPIONs by means of hot homogenization technique using cetyl palmitate as lipid matrix and polyethylene glycol-modified phospholipids (PEG lipids), in order to achieve a PEG-based anti-fouling coating on SLN surface.
CITATION STYLE
Vischio, F., Depalo, N., Iacobazzi, R. M., Scavo, M. P., Villa, S., Canepa, F., … Curri, M. L. (2020). Magnetically Targeted Delivery of Sorafenib Through Magnetic Solid Lipid Nanoparticles Towards Treatment of Hepatocellular Carcinoma. In NATO Science for Peace and Security Series A: Chemistry and Biology (pp. 277–278). Springer Science and Business Media B.V. https://doi.org/10.1007/978-94-024-2041-8_30
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