rs2572431 polymorphism on chromosome 8 is associated with individual differences in anxiety related coping modes

Abstract

Objective: The role of genetic factors in the interplay between anxiety-related coping and personality has been the subject of interest in numerous previous studies. The current study focused on anxiety-related coping modes, namely repression versus sensitization (i.e., cognitive avoidance versus vigilance), and the single nucleotide polymorphism (SNP) rs2572431. An association between this SNP and anxiety-related personality traits has previously been shown in a genome wide association study, thus further investigation of the relationship between this SNP and anxiety-related coping seems warranted. Methods: In the present study, N = 880 mostly Caucasian participants (n = 269 males and n = 611 females; mean-age: 23.88, SD = 7.19) filled in a personality questionnaire assessing individual differences in cognitive avoidance and vigilance, and all participants were genotyped for rs2572431. Results: Participants homozygous for the T-allele in rs2572431 showed the highest vigilance scores in all scenarios tested. This is in line with findings from an earlier genome wide association study demonstrating that the T-allele is also associated with higher neuroticism scores. Conclusion: The current study yields evidence for the role of rs2572431 in the molecular genetic underpinnings of coping modes and, more broadly, for its connection with personality.