The FAD dependent amine oxidases in relation to developmental state of enterocyte

Abstract

Epithelial cells from bovine and guinea pig small intestines contain monoamine and polyamine oxidases with MAO-A preponderance at any maturational stage. For either species, K(m) values for 5HT and N1acetylspermine remain throughout cellular maturation on the same levels, whereas the V(max) values do not. For serotonin, the dividing crypt cells showed in cow lower and in guinea pig higher V(max) than the mature cells: for N1acetylspermine, mature cells, independently of species, showed lower V(max).