1 + 1 + 1 + 1 = ?: Variable effects of combined substances

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Abstract

This case discusses the ubiquitous but poorly understood pharmacodynamic interactions between multiple anesthetic, sedative, and opioid agents.

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Silipo, A. T., Planinsic, R. M., Wittwer, E. D., Sprung, J., & Nicholson, W. T. (2015). 1 + 1 + 1 + 1 = ?: Variable effects of combined substances. In A Case Approach to Perioperative Drug-Drug Interactions (pp. 123–127). Springer New York. https://doi.org/10.1007/978-1-4614-7495-1_23

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