Natalizumab adverse events are rare in patients with multiple sclerosis

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Abstract

Objective: To assess the prevalence and the profile of adverse events (AE) of natalizumab in patients with multiple sclerosis (MS). Methods: Data collection from neurologists attending to patients with MS at specialized units in Brazil. Results: Data from 103 patients attending the infusion centers of 16 MS units in 9 Brazilian states were included in the study. The total number of infusions was 1,042. Seventy-nine patients (76.7%) did not present any AE. Twenty-four patients (23.3%) presented only mild AE. There were three major AE, including two deaths. These three occurrences, although not necessarily being drug-related, must be taken into consideration. Conclusion: The profile of AEs for natalizumab shows that 97% of patients have none or only mild AE. However, still due to safety worries, the use of this medication should be restricted to MS units under the care of specialized neurologists.

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Fragoso, Y. D., Alves-Leon, S. V., Arruda, W. O., Carvalho, M. de J., Comini-Frota, E. R., Corrêa, É. C., … Satomi, M. (2013). Natalizumab adverse events are rare in patients with multiple sclerosis. Arquivos de Neuro-Psiquiatria, 71(3), 137–141. https://doi.org/10.1590/S0004-282X2013000300002

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