Ge-68/Ga-68 Generators and Current Approach to Ga-68 Radiopharmaceuticals

Abstract

The short half-life, favourable nuclear decay properties, convenient availability through [Germanium-68 (Ge-68)/ Gallium-68 (Ga-68)] generators, ease of radiolabeling through automated synthesis module and kit methodology and possible combination with Lutetium-177/Yttrium-90 as a theranostic pair for treatment, the radiometal Gallium-68 is increasingly used in diagnostic positron emission tomography. This review discusses the properties of Ge-68/Ga-68 generators, bifunctional chelators that can be efficiently radiolabeled with Ga-68, the way of preparation of Ga-68 radiopharmaceuticals with their quality control.