COVID‐19 and genetic variants of protein involved in the SARS‐CoV‐2 entry into the host cells

89Citations
Citations of this article
154Readers
Mendeley users who have this article in their library.

Abstract

The recent global COVID‐19 public health emergency is caused by SARS‐CoV‐2 infections and can manifest extremely variable clinical symptoms. Host human genetic variability could influence susceptibility and response to infection. It is known that ACE2 acts as a receptor for this pathogen, but the viral entry into the target cell also depends on other proteins. The aim of this study was to investigate the variability of genes coding for these proteins involved in the SARS‐ CoV‐2 entry into the cells. We analyzed 131 COVID‐19 patients by exome sequencing and examined the genetic variants of TMPRSS2, PCSK3, DPP4, and BSG genes. In total we identified seventeen variants. In PCSK3 gene, we observed a missense variant (c.893G>A) statistically more frequent compared to the EUR GnomAD reference population and a missense mutation (c.1906A>G) not found in the GnomAD database. In TMPRSS2 gene, we observed a significant difference in the frequency of c.331G>A, c.23G>T, and c.589G>A variant alleles in COVID‐19 patients, compared to the corresponding allelic frequency in GnomAD. Genetic variants in these genes could influence the entry of the SARS‐CoV‐2. These data also support the hypothesis that host genetic variability may contribute to the variability in infection susceptibility and severity.

Cite

CITATION STYLE

APA

Latini, A., Agolini, E., Novelli, A., Borgiani, P., Giannini, R., Gravina, P., … Novelli, G. (2020). COVID‐19 and genetic variants of protein involved in the SARS‐CoV‐2 entry into the host cells. Genes, 11(9), 1–8. https://doi.org/10.3390/genes11091010

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free