Background: Narciclasine (NCS) is an Amaryllidaceae alkaloid isolated from Narcissus tazetta bulbs. NCS has inhibitory effects on a broad range of biological activities and thus has various potential practical applications. Here we examine how NCS represses plant root growth.Results: Results showed that the inhibition of NCS on cell division in Arabidopsis root tips and its effects on cell differentiation are concentration-dependent; at low concentrations (0.5 and 1.0 μM) NCS preferentially targets mitotic cell cycle specific/cyclin complexes, whereas at high concentration (5.0 μM) the NCS-stimulated accumulation of Kip-related proteins (KRP1 and RP2) affects the CDK complexes with a role at both G1/S and G2/M phases.Conclusions: Our findings suggest that NCS modulates the coordination between cell division and differentiation in Arabidopsis root tips and hence affects the postembryonic development of Arabidopsis seedlings. © 2011 Na et al; licensee BioMed Central Ltd.
CITATION STYLE
Na, X., Hu, Y., Yue, K., Lu, H., Jia, P., Wang, H., … Bi, Y. (2011). Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips. BMC Plant Biology, 11. https://doi.org/10.1186/1471-2229-11-184
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