Development of oral capsules from Enterica herbal decoction-a traditional remedy for typhoid fever in Ghana

Abstract

The study aimed to develop oral capsules from Enterica herbal decoction used in Ghana for the treatment of typhoid fever and produced by the Centre for Scientific Research into Plant Medicine (CSRPM). The amount of dry extract per dose (30ml) of Enterica and the wavelength of maximum absorption (λmax) of aqueous solutions of Enterica extract were determined. Light magnesium carbonate (LMC) and maize starch (MS) were employed as absorbents at various concentrations in the preparation of granules of the extract. The % loss in weight, size distribution and flow properties of the granules were evaluated. Enterica oral capsules were formulated using LMC at 22 mg/dose of extract and the dissolution properties of the granules and capsules were determined by UV-VIS spectrophotometry. The dry Enterica extract/dose was 190.1 ± 0.12 mg and λmax was 356 nm. The loss of granules was 2.07-7.31 %w/w for LMC and 2.73-7.81 %w/w for MS. LMC granules (22 mg/dose) prepared for encapsulation exhibited good flow properties. The granules for encapsulation exhibited optimal release of extract (86.08 ± 1.64 % at 45 min) in aqueous medium. The formulated capsules passed the British Pharmacopoeia uniformity of weight, disintegration and dissolution tests. Enterica oral capsules can be used as a substitute for Enterica decoction for the treatment of typhoid fever.