Determining the enantioselectivity of chiral catalysts by mass spectrometric screening of their racemic forms

Abstract

The enantioselectivity of a chiral catalyst can be determined from its racemic form by mass spectrometric screening of a nonequal mixture of two mass-labeled quasienantiomeric substrates. The presented method opens up new possibilities for evaluating catalyst structures that are not readily available in enantiomerically pure form. © 2011 American Chemical Society.