Skip to main content

Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL

Citations of this article
Mendeley users who have this article in their library.

This artice is free to access.


For children and young adults with T-lineage acute lymphoblastic leukemia (T-ALL), event free survival following relapse is < 10%. We recently showed that rearrangements of the mixed lineage leukemia gene (KMT2A-R) are associated with induction failure and an inferior survival in T-ALL. Because there are currently no molecular features that inform treatment strategies in T-ALL, we hypothesized that transcriptional alterations related to KMT2A-R and MLLT10-R T-ALL could identify biologically relevant genes and signaling pathways for the development of targeted therapies for these groups of patients. We analyzed microarray data from a retrospective cohort of 100 T-ALL patients to identify novel targets for KMT2A (n = 12) or MLLT10 (n = 9) chimeras. We identified 330 probe sets that could discriminate between these groups, including novel targets, like RUNX2, TCF4 or MYO6. The results were further validated in two independent data sets and the functional networks were analyzed to identify pathways that may be of pathogenic or therapeutic relevance.




Kang, H., Sharma, N. D., Nickl, C. K., Devidas, M., Loh, M. L., Hunger, S. P., … Matlawska-Wasowska, K. (2018). Dysregulated transcriptional networks in KMT2A- and MLLT10-rearranged T-ALL. Biomarker Research, 6(1).

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free