The cognitive effect of uric acid in idiopathic Parkinson’s patients

Abstract

Objective:High serum uric acid level (sUA) has been associated with decreased Parkinson's disease risk, slow disease progression, good cognitive performance and low dementia risk. In this study, the relation of dementia and uric acid levels was investigated in idiopathic Parkinson's patients that are known to be associated with low sUA. Methods:Patients files of patients, who were diagnosed with idiopathic Parkinson's disease and have applied between dates 01.01.2009-31.01.2019, have been scanned retrospectively. Their age, gender, marital status, uric acid level and the presence of dementia were recorded. A total of 126 patients between ages 18-90 with creatinine levels below 1.25 mg/dl and no diagnosis of gout have been included in the study. Results:Among 126 patients included in the study, 68 (54%) were male, 93 (73.81%) were married, and 37 (29.37%) patients were diagnosed with dementia. There was a statistically significant difference between groups with or without dementia diagnosis with regard to age (p:0.006) and marital status (p:0.007). Mean uric acid level was determined to be 4.6 mg/dl for the patients. There was no statistically significant difference between the two groups when this value was taken as reference (p:0.328). However, the number of patients diagnosed with dementia was relatively lower in the group with higher uric acid level. Conclusion:The fact that median uric acid levels of our patients were within the interval recognized to be normal and the patients had relatively higher sUA levels in non-dementia group suggests that high sUA levels within normal interval may be protective.