Modeling the device behavior of biological and synthetic nanopores with reduced models

7Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.

Abstract

Biological ion channels and synthetic nanopores are responsible for passive transport of ions through a membrane between two compartments. Modeling these ionic currents is especially amenable to reduced models because the device functions of these pores, the relation of input parameters (e.g., applied voltage, bath concentrations) and output parameters (e.g., current, rectification, selectivity), are well defined. Reduced models focus on the physics that produces the device functions (i.e., the physics of how inputs become outputs) rather than the atomic/molecular-scale physics inside the pore. Here, we propose four rules of thumb for constructing good reduced models of ion channels and nanopores. They are about (1) the importance of the axial concentration profiles, (2) the importance of the pore charges, (3) choosing the right explicit degrees of freedom, and (4) creating the proper response functions. We provide examples for how each rule of thumb helps in creating a reduced model of device behavior.

Cite

CITATION STYLE

APA

Boda, D., Valiskó, M., & Gillespie, D. (2020). Modeling the device behavior of biological and synthetic nanopores with reduced models. Entropy, 22(11), 1–26. https://doi.org/10.3390/e22111259

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free