Role of Pyridoxine in Alleviating Cardiovascular Diseases: A Brief Review

Abstract

Micronutrients are class of dietary components which are highly essential for the optimal health, growth, and development. These nutrients can overcome birth defects, maternal impairment, and increased risk of death. According to 2017 statistics, around 2 billion people in the developing countries are affected by micronutrient deficiency. There are around 13 essential vitamins which are found in nature. Vitamin B is more important as it plays a vital role in maintaining good health and well-being. Among several existing forms, the native and active form of vitamin B6 is PLP (pyridoxal 5-phosphate). PLP is a co-factor for several biochemical reactions and plays an imperative role in synthesis of amino acids, carbohydrates and fatty acids. Vitamin B6 supplementation in RDA showed to be highly health promising in controlling several clinical alignments such as cardiovascular disease, diabetes, neurological disease, premenstrual syndrome, stroke, peripheral vascular disease, coronary artery disease, pellagra skin disease, ataxia, hyperacuosis, suppression of colon tumor genesis and hyper irritability. Recently, it has been reported that 43.8% people are suffering from cardiovascular disease followed by stroke (16.8%) and is also expected to reach up to1.1 trillion by the end of 2035. It has been found that vitamin B6 lowers Homocystein in blood, which damages the inner linings of arteries causing blood clots and thereby reducing the symptoms of cardiovascular diseases. In addition to it humans have to depend on dietary sources of vitamin B6 which are produced by plants, fungi and bacteria. The present review currently focuses on the action of Vitamin B6 in the management of cardiovascular diseases.