The nutritional supply of iodine and selenium affects thyroid hormone axis related endpoints in mice

17Citations
Citations of this article
39Readers
Mendeley users who have this article in their library.

Abstract

Selenium and iodine are the two central trace elements for the homeostasis of thyroid hormones but additional trace elements such as iron, zinc, and copper are also involved. To compare the primary effects of inadequate intake of selenium and iodine on the thyroid gland, as well as the target organs of thyroid hormones such as liver and kidney, mice were subjected to an eight-week dietary intervention with low versus adequate selenium and iodine supply. Analysis of trace element levels in serum, liver, and kidney demonstrated a successful intervention. Markers of the selenium status were unaffected by the iodine supply. The thyroid gland was able to maintain serum thyroxine levels even under selenium-deficient conditions, despite reduced selenoprotein expression in liver and kidney, including deiodinase type 1. Thyroid hormone target genes responded to the altered selenium and iodine supply, whereas the iron, zinc, and copper homeostasis remained unaffected. There was a notable interaction between thyroid hormones and copper, which requires further clarification. Overall, the effects of an altered selenium and iodine supply were pronounced in thyroid hormone target tissues, but not in the thyroid gland.

Cite

CITATION STYLE

APA

Lossow, K., Renko, K., Schwarz, M., Schomburg, L., Schwerdtle, T., & Kipp, A. P. (2021). The nutritional supply of iodine and selenium affects thyroid hormone axis related endpoints in mice. Nutrients, 13(11). https://doi.org/10.3390/nu13113773

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free