This review introduces recent concepts in innate immunity highlighting some of the latest exciting findings. These include: the discovery of the initiator of pyroptosis, Gasdermin D, and mechanisms of inflammatory caspases in innate immune signaling; the formation of oligomeric signalosomes downstream of innate immune receptors; mechanisms that shape innate immune responses, such as cellular homeostasis, cell metabolism, and pathogen viability; rapid methods of cell-to-cell communication; the interplay between the host and its microbiome and the concept of innate immunological memory. Furthermore, we discuss open questions and illustrate how technological advances, such as CRISPR/Cas9, may provide important answers for outstanding questions in the field of innate immunity.
CITATION STYLE
Pelka, K., & De Nardo, D. (2018). Emerging concepts in innate immunity. In Methods in Molecular Biology (Vol. 1714, pp. 1–18). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7519-8_1
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