Voriconazole is the preferred antifungal agent for Aspergillus infections. Therapeutic drug monitoring is recommended to achieve target concentrations and prevent toxicity. However, variable pharmacokinetics, cytochrome P450 polymorphisms, and extensive drug-drug interactions can contribute to subtherapeutic concentrations. We report a voriconazole "boosting" effect of omeprazole to achieve target concentrations for the treatment of Aspergillus in a patient who had persistently subtherapeutic trough concentrations. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
CITATION STYLE
Boyd, N. K., Zoellner, C. L., Swancutt, M. A., & Bhavan, K. P. (2012). Utilization of omeprazole to augment subtherapeutic voriconazole concentrations for treatment of aspergillus infections. Antimicrobial Agents and Chemotherapy, 56(11), 6001–6002. https://doi.org/10.1128/AAC.00700-12
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