Abstract
E2F family of transcription factor acts as central modulator for important cellular events including cell cycle progression, apoptosis, and DNA damage response. E2F1 regulates G1/S-phase transition of cell cycle transactivating a variety of genes involved in chromosomal DNA replication, including its own promoter. E2F1 is regulated in a cell cycle-dependent manner, principally through its temporal association with pocket protein family member, retinoblastoma. Pocket proteins, in turn, regulated through phosphorylation by cyclin-dependent kinase (CDK). Different E2F family exhibits distinct cell cycle and apoptotic activities. This review focuses on E2F1 function and its putative role in colon cancer.
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Vasavi, I., Prathyusha, A. M. V. N., Ramesh, M., Kumar, K. S., Naidu, B. P., Bramhachari, P. V., … Ganesh, P. R. C. (2018). E2F1: Transcriptional machinery in colon cancer. In Role of Transcription Factors in Gastrointestinal Malignancies (pp. 297–304). Springer Singapore. https://doi.org/10.1007/978-981-10-6728-0_20
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