Impaired erythrocyte calcium homeostasis in β-thalassemia

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Abstract

Intracellular calcium (Ca) concentration in erythrocytes (RBCs) is controlled by a low passive influx through a relatively impermeable membrane and by active efflux catalyzed by Ca2+,Mg2+-ATPase. Since precipitation of α-globin chains in thalassemic RBCs may interfere with normal membrane function, we studied the RBC intracellular Ca content and the RBC membrane Ca2+,Mg2+-ATpase activity in two groups of patients with nonsplenectomized (n = 9) and splenectomized (n = 9) β-thalassemia intermedia and in two groups of matched controls. The mean ± SD Ca concentration in the nonsplenectomized (n = 12) and splenectomized (n = 6) controls were 6.1 ± 6.0 and 5.8 ± 3.4 μmol Ca per liter of RBCs, respectively, compared with 26.0 ± 7.6 (P

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Shalev, O., Mogilner, S., Shinar, E., Rachmilewitz, E. A., & Schrier, S. L. (1984). Impaired erythrocyte calcium homeostasis in β-thalassemia. Blood, 64(2), 564–566. https://doi.org/10.1182/blood.v64.2.564.bloodjournal642564

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