The graph of cellular automata applied for modelling tumour induced angiogenesis

Abstract

Angiogenesis is the process of formation of vascular network. Blocking tumour induced angiogenesis is one of the treatments applied in oncology. Research involving computer simulations looking for the rules influencing the structure of vascular network and its functionality. This paper summarizes the applications of Graph of Cellular Automata modelling tool, developed by the Author, for modelling Tumour Induced Angiogenesis. Vascular network which is modelled by the graph interacts with surrounding tissue represented by the lattice of automata. The network is developed and reorganized accordingly to locally acting factors (stimulators and inhibitors). The model includes blood flow calculations in a modelled vascular network. © 2014 Springer-Verlag.