The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from central China

10Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

Purpose: The mutation status and prognostic value of PIK3CA in breast cancer were widely investigated, which showed significant difference among the patients from vast areas around the world. In this study, the frequency, distribution, bias, and burden of PIK3CA mutations and their relationships with clinicopathologic variables and prognostic significances were investigated in the breast cancer patients from Central China. Materials and methods: Somatic mutations in exon 9 and exon 20 of PIK3CA gene were analyzed using Sanger sequencing combining with targeted next generation sequencing in 494 breast cancer patients from Central China. The correlations between PIK3CA mutations and clinicopathological characteristics and the prognostic values of multiple PIK3CA mutation statuses were evaluated. Results: PIK3CA mutations were found in 38% of the patients and associated with estrogen receptor-positive, progesterone receptor-positive, low Ki67 labeling index, and luminal/human epidermal growth factor receptor 2-enriched subtypes. Meanwhile, the prognosis of the total patients and the patients in old diagnostic age, progesterone receptor-negative, low Ki67 labeling index, and luminal/human epidermal growth factor receptor 2-enriched subgroups was significantly related to PIK3CA mutations. Most interestingly, the distribution, bias, and burden of PIK3CA mutations were correlated with different clinical, pathological, and molecular features as well as distinct prognostic implications in multiple breast cancer subgroups. Conclusion: The frequency, distribution, bias, and burden of PIK3CA mutations were associated with various clinical, pathological, and molecular characteristics in the breast cancer patients from Central China. These different mutation statuses can be used as potential indicators of prognosis in multiple breast cancer subgroups.

References Powered by Scopus

Cancer statistics in China, 2015

16880Citations
N/AReaders
Get full text

Comprehensive molecular portraits of human breast tumours

9499Citations
N/AReaders
Get full text

Gene expression profiling predicts clinical outcome of breast cancer

8181Citations
N/AReaders
Get full text

Cited by Powered by Scopus

PIK3CA gene mutations in solid malignancies: Association with clinicopathological parameters and prognosis

66Citations
N/AReaders
Get full text

Up-regulation of SPC25 promotes breast cancer

29Citations
N/AReaders
Get full text

Spectrum of PIK3CA/AKT mutations across molecular subtypes of triple-negative breast cancer

13Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Wu, H., Wang, W., Du, J., Li, H., Wang, H., Huang, L., … Lin, W. (2019). The distinct clinicopathological and prognostic implications of PIK3CA mutations in breast cancer patients from central China. Cancer Management and Research, 11, 1473–1492. https://doi.org/10.2147/CMAR.S195351

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

56%

Professor / Associate Prof. 2

22%

Lecturer / Post doc 1

11%

Researcher 1

11%

Readers' Discipline

Tooltip

Medicine and Dentistry 7

70%

Agricultural and Biological Sciences 1

10%

Nursing and Health Professions 1

10%

Engineering 1

10%

Save time finding and organizing research with Mendeley

Sign up for free