Abstract
A practical, chemoenzymatic, four-step synthesis of the LTD4 antagonist MK-0679 is described. The key steps are enzymatic hydrolysis of the prochiral diester to the ester-acid in 99% enantiomeric excess followed by aluminum mediated amidation of the methyl ester to afford MK-0679 in high overall yield. This synthesis is superior to the synthesis of the racemate MK-0571. © 1992 IUPAC
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CITATION STYLE
APA
Bhupathy, M., Hughes, D. L., Amato, L. S., Bergan, J. J., Leazer, J. L., Lovelace, T. C., … Shinkai, I. (1992). Enzymes and practical asymmetric synthesis. Pure and Applied Chemistry, 64(12), 1939–1944. https://doi.org/10.1351/pac199264121939
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