Ventilatory function in infants with cystic fibrosis: Physiological assessment of inhalation therapy

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Abstract

Respiratory function studies were carried out in 18 infants with cystic fibrosis who were less than 9 months of age when first seen. In 9 infants who had no clinical evidence of chest infection when first seen, thoracic gas volume was increased in 3 and conductance reduced in 4. The other 9 infants had symptoms of chest infection when first studied, and they too showed an increased thoracic gas volume and reduced conductance. Treatment with intermittent inhalations administered with a nebulizer and face-mask resulted in return to normal of these abnormalities in respiratory function in all infants.

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Phelan, P. D., Gracey, M., Williams, H. E., & Anderson, C. M. (1969). Ventilatory function in infants with cystic fibrosis: Physiological assessment of inhalation therapy. Archives of Disease in Childhood, 44(235), 393–400. https://doi.org/10.1136/adc.44.235.393

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