DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension of 8,123 bp of genomic sequence and encodes a transcript of 1.8 kb that is expressed in all tissues evaluated. The predicted amino acid sequence shows a high similarity to a yeast DEAD-box RNA helicase (Dbp9b) involved in ribosome biogenesis. The new helicase maps to 7p12, a region of frequent chromosome amplifications in glioblastomas involving the epidermal growth factor receptor (EGFR) gene. Nevertheless, co-amplification of DDX26 with EGFR was not detected in nine tumors analyzed.
CITATION STYLE
Camargo, A. A., Nunes, D. N., Samaia, H. B., Liu, L., Collins, V. P., Simpson, A. J. G., & Dias-Neto, E. (2001). Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12. Brazilian Journal of Medical and Biological Research, 34(10), 1237–1245. https://doi.org/10.1590/S0100-879X2001001000002
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