In vitro susceptibility of P. falciparum populations from Colombia and Tanzania to a new synthetic peroxide (OZ277)

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Abstract

Sensitivity of Plasmodium falciparum populations from Colombia (N = 38) and Tanzania (N = 45) to the newly developed, fully synthetic peroxide OZ277 was investigated using a standard isotopic microtest. OZ277 showed excellent activity against chloroquine-resistant isolates in Colombia with median IC 50 [range] values of 2.5 ng/mL [0.34-8] (4.4 nM [0.6-14]) and Tanzania with 1.5 ng/mL [0.22-10] (2.65 nM [0.4-17.7]). The potency of OZ277 was similar to artesunate, showing median IC50 values of 1.5 ng/mL [0.42-8.6] (3.8 nM [1.1-22.3]) and 1.8 ng/mL [0.2-10] (4.7 nM [0.5-26.04]) in Colombia and Tanzania, respectively. These results support the development of this new antimalarial compound. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.

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Osorio, L., Murillo, C., Aponte, S., Mayagaya, V., Scheurer, C., Brun, R., … Wittlin, S. (2007). In vitro susceptibility of P. falciparum populations from Colombia and Tanzania to a new synthetic peroxide (OZ277). American Journal of Tropical Medicine and Hygiene, 76(6), 1024–1026. https://doi.org/10.4269/ajtmh.2007.76.1024

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