Abstract
An asymmetrical dimer of kaurane diterpene and monoterpene and four novel diterpenes were isolated from the roots of Croton limae, along with kaempferol-3-O-glucoside, ombuin-3-O-rutinoside and acetyl aleuritolic acid. The cytotoxic activity of the kaurane diterpene was evaluated against colorectal adenocarcinoma (HCT-116), ovarian carcinoma (OVCAR-8) and glioma (SF-295) cell lines, exhibiting IC50values of 7.14, 8.19 and > 10 μg mL-1, respectively.
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Sousa, A. H., Silva, J. N., Maria, L. S., Braz-Filho, R., Costa-Lotufo, L. V., Araújo, A. J., … Lima, M. A. S. (2015). New terpenoids from Croton limae (Euphorbiaceae). Journal of the Brazilian Chemical Society, 26(8), 1565–1572. https://doi.org/10.5935/0103-5053.20150124
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