Role of IL-1 and tumor necrosis factor in coxsackie virus-induced autoimmune myocarditis.

  • Lane J
  • Neumann D
  • Lafond-Walker A
  • et al.
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Abstract

We have previously reported that B10.A (H-2a) mice, which are resistant to the induction of postcoxsackievirus autoimmune myocarditis, become susceptible upon treatment with LPS, IL-1, or TNF. In this study, we show that the development of autoimmune myocarditis is associated with infiltration of the heart by inflammatory cells that secrete the cytokines IL-1 and TNF. Local secretion of these cytokines contributes to increased levels of IL-1 and TNF in the serum. Thus, local production of cytokines promotes the induction of this postinfectious autoimmune disease.

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Lane, J. R., Neumann, D. A., Lafond-Walker, A., Herskowitz, A., & Rose, N. R. (1993). Role of IL-1 and tumor necrosis factor in coxsackie virus-induced autoimmune myocarditis. The Journal of Immunology, 151(3), 1682–1690. https://doi.org/10.4049/jimmunol.151.3.1682

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