Proteins encoded by non-oncogenic adenovirus type 5 and oncogenic adenovirus type 12 differentially affect expression of a number of cellular genes. We have used cDNA micro array analysis to identify a cellular gene that is expressed in Ad12- but not in Ad5-transformed cells. This cellular gene was found to be the gene encoding follistatin-related protein, a TGF-β inducible gene. Consistently, a constitutive factor binding to Smad binding elements was found in adenovirus type 12-transformed cells. © 2000 Federation of European Biochemical Societies.
Vertegaal, A. C. O., Kuiperij, H. B., Van Laar, T., Scharnhorst, V., Van der Eb, A. J., & Zantema, A. (2000). cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells. FEBS Letters, 487(2), 151–155. https://doi.org/10.1016/S0014-5793(00)02339-5