Iron metabolism in liver cancer stem cells

20Citations
Citations of this article
33Readers
Mendeley users who have this article in their library.

Abstract

Cancer stem cells (CSC) which have been identified in several tumors, including liver cancer, represent a particular subpopulation of tumor cells characterized by properties similar to those of adult stem cells. Importantly, CSC are resistant to standard therapies, thereby leading to metastatic dissemination and tumor relapse. Given the increasing evidence that iron homeostasis is deregulated in cancer, here we describe the iron homeostasis alterations in cancer cells, particularly in liver CSC. We also discuss two paradoxically opposite iron manipulation-strategies for tumor therapy based either on iron chelation or iron overload-mediated oxidant production leading to ferroptosis. A better understanding of iron metabolism modifications occurring in hepatic tumors and particularly in liver CSC cells may offer new therapeutic options for this cancer, which is characterized by increasing incidence and unfavorable prognosis.

References Powered by Scopus

Identification of human brain tumour initiating cells

6484Citations
N/AReaders
Get full text

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

5093Citations
N/AReaders
Get full text

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

3642Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Ferroptosis in Hepatocellular Carcinoma: Mechanisms, Drug Targets and Approaches to Clinical Translation

37Citations
N/AReaders
Get full text

Regulation of ferroptosis by non‑coding RNAs in the development and treatment of cancer (Review)

35Citations
N/AReaders
Get full text

Research mechanisms of and pharmaceutical treatments for ferroptosis in liver diseases

27Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Recalcati, S., Correnti, M., Gammella, E., Raggi, C., Invernizzi, P., & Cairo, G. (2019). Iron metabolism in liver cancer stem cells. Frontiers in Oncology. Frontiers Media S.A. https://doi.org/10.3389/fonc.2019.00149

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 9

69%

Professor / Associate Prof. 2

15%

Researcher 2

15%

Readers' Discipline

Tooltip

Medicine and Dentistry 6

43%

Agricultural and Biological Sciences 3

21%

Biochemistry, Genetics and Molecular Bi... 3

21%

Chemistry 2

14%

Save time finding and organizing research with Mendeley

Sign up for free