Background: To correlate parameters of Ultrasonography-guided Diffuse optical tomography (US-DOT) with pharmacokinetic features of Dynamic contrast-enhanced (DCE)-MRI and pathologic markers of breast cancer. Methods: Our institutional review board approved this retrospective study and waived the requirement for informed consent. Thirty seven breast cancer patients received US-DOT and DCE-MRI with less than two weeks in between imaging sessions. The maximal total hemoglobin concentration (THC) measured by US-DOT was correlated with DCE-MRI pharmacokinetic parameters, which included Ktrans, kep and signal enhancement ratio (SER). These imaging parameters were also correlated with the pathologic biomarkers of breast cancer. Results: The parameters THC and SER showed marginal positive correlation (r = 0.303, p = 0.058). Tumors with high histological grade, negative ER, and higher Ki-67 expression ≥20 % showed statistically higher THC values compared to their counterparts (p = 0.019, 0.041, and 0.023 respectively). Triple-negative (TN) breast cancers showed statistically higher Ktrans values than non-TN cancers (p = 0.048). Conclusion: THC obtained from US-DOT and Ktrans obtained from DCE-MRI were associated with biomarkers indicative of a higher aggressiveness in breast cancer. Although US-DOT and DCE-MRI both measured the vascular properties of breast cancer, parameters from the two imaging modalities showed a weak association presumably due to their different contrast mechanisms and depth sensitivities.
CITATION STYLE
Kim, M. J., Su, M. Y., Yu, H. J., Chen, J. H., Kim, E. K., Moon, H. J., & Choi, J. S. (2016). US-localized diffuse optical tomography in breast cancer: Comparison with pharmacokinetic parameters of DCE-MRI and with pathologic biomarkers. BMC Cancer, 16(1). https://doi.org/10.1186/s12885-016-2086-7
Mendeley helps you to discover research relevant for your work.