Plant-derived compounds have played an important role in the development of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide, and paclitaxel (Taxol®). Several promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and Combretastatin A4 phosphate. Recently, plants have yielded several agents showing anti-AIDS activity, and one of these, (+)-calanolide A, is in clinical development.
CITATION STYLE
Cragg, G. M., & Newman, D. J. (2003). Plants as a source of anti-cancer and anti-HIV agents. In Annals of Applied Biology (Vol. 143, pp. 127–133). Association of Applied Biologists. https://doi.org/10.1111/j.1744-7348.2003.tb00278.x
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