Prodrugs of Amides, Imides and Other NH-acidic Compounds

Abstract

The term ‘NH-acidic compound,’ in the context of this chapter, refers to amides, carbamates, ureas, imides, and sulfonamides (Figure 1). However, the above term will not include amines, as they are discussed in a previous chapter. This chapter reviews various prodrug strategies for modifying the physical, chemical, and biochemical properties of NH-acidic compounds. Synthetic methodologies are not covered, as this information is readily available from the primary references cited.