Reactions of halopyridines with alkali metal phenoxides in a two phase liquid-solid catalytic system, rather than in a liquid-liquid phase transfer catalytic system, make it possible to prepare 2-, 3-, and 4-phenoxypyridines from unactivated bromo- or chloropyridines and 2-chloropicolines. In polyhalogenated pyridines only α- and γ-halogen atoms undergo substitution. 7, 8-Dibromo-6-azaphenoxane has been prepared by the reaction of 2,3,5,6-tetrabromopyridine with the dipotassium salt of pyrocatechol. © 1988 Plenum Publishing Corporation.
CITATION STYLE
Abele, e. M., Gol’dberg, Y. S., Gavars, M. P., Gaukhman, A. P., & Shimanskaya, M. V. (1988). Synthesis of phenoxypyridines under phase transfer catalysis conditions. Chemistry of Heterocyclic Compounds, 24(3), 290–294. https://doi.org/10.1007/BF00475326
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