In this chapter, we review some recent methods designed for detecting recurrent copy number regions, that is, genomic regions that show evidence of being altered in a set of samples. We analyze Affymetrix SNP6 data from 87 Her2-type breast tumors from a recent study using three different methods, showing different definitions and features of common regions: studying heterogeneity in copy number profiles, refining candidates for driver oncogenes, and consolidating broad amplifications. © Springer Science+Business Media, LLC 2013.
CITATION STYLE
Rueda, O. M., Diaz-Uriarte, R., & Caldas, C. (2013). Finding common regions of alteration in copy number data. Methods in Molecular Biology, 973, 339–353. https://doi.org/10.1007/978-1-62703-281-0_21
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