Redetermination of para-aminopyridine (fampridine, EL-970) at 150 K

Abstract

The structure of fampridine (EL-970) or 4-aminopyridine. C 5H6N2, has been redetermined at 150 K. The room-temperature structure has been reported previously [Chao & Schempp (1977). Acta Cryst. B33, 1557-1564]. Pyramidalization at the amine N atom occurs in fampridine, with the N atom 0.133 (11) Å from the plane of the three C/H/H atoms to which it is bonded; the interplanar angle between the pyridyl ring and NH2 group is 21 (2)°. Aggregation in the solid state occurs by N-H⋯N and N-H⋯π(pyridine) interactions with N⋯N and N⋯π(centroid) distances of 2.9829 (18) and 3.3954 (15) Å, respectively; a C-H⋯π(pyridine) contact completes the intermolecular interactions [C⋯π(centroid) = 3.6360 (16) Å]. © 2005 International Union of Crystallography Printed in Great Britain - all rights reserved.