In this chapter, we review the current knowledge of the structure of the ligsands and receptors of the insulin/insulin-like growth factors (IGFs) peptide family, their structure-function relationships and mapping of the binding sites on the ligands and receptors by site-directed mutagenesis. We discuss a plausible bivalent crosslinking binding model that explains the complex binding properties of insulin and the IGFs.
CITATION STYLE
De Meyts, P., & Whittaker, J. (2002). Structure-Function Relationships of Insulin and Insulin-Like Growth factor-I Receptor Binding. In Insulin & Related Proteins - Structure to Function and Pharmacology (pp. 131–149). Springer Netherlands. https://doi.org/10.1007/0-306-47582-0_11
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