CT Perfusion

Abstract

The brain is one of the most metabolically demanding organs in the body but has virtually no internal energy reserves, necessitating constant high blood flow to provide oxygen and nutrients. Any perturbation in this flow is associated with significant morbidity and mortality. Because of its critical importance for health, a variety of techniques have been developed to quantify and map cerebral blood flow, including CT perfusion. In this chapter, we will review key technical considerations for the acquisition of CT perfusion data and discuss theoretical and practical aspects of image processing and interpretation. We will also discuss applications of the technique with an emphasis on the role of CT perfusion in acute ischaemic stroke.