Extracellular vesicle (EV) shedding is a biologically conserved cellular process across virtually every cell type. In cancer, EVs shed from tumor and stromal cells to the tumor microenvironment play a major role in determining tumor fate, which to a large extent is dictated by the biologically active cargo contained in EVs. Current understanding of various cancer-associated EVs has enabled the outlining of mechanistic connections between cargo and tumor-promoting functions. In this chapter, we describe examples of EV-mediated communication between tumor cells and stromal cells, highlighting the molecular constituents responsible for pro-tumorigenic effects. Furthermore, we discuss the roles of matrix-degrading EVs in cell invasion. Finally, we summarize research on the potential use of EVs as a novel approach to cancer therapeutics.
CITATION STYLE
Boomgarden, A. C., Sheehan, C., & D’Souza-Schorey, C. (2020). Extracellular Vesicles in the Tumor Microenvironment: Various Implications in Tumor Progression. In Advances in Experimental Medicine and Biology (Vol. 1259, pp. 155–170). Springer. https://doi.org/10.1007/978-3-030-43093-1_9
Mendeley helps you to discover research relevant for your work.