Studies on Azole Compounds. III. Reactions of Oxazole N-Oxides with Phosphoryl Chloride and Acetic Anhydride

Abstract

Six kinds of 2-aryloxazole N-oxide derivatives were prepared, and their reactions with phosphoryl chloride and acetic anhydride were studied. Methyl group located on the 4-position of 2-aryloxazole N-oxide was easily subjective to nucleophilic attack as an active methyl group in the reaction with phosphoryl chloride or acetic anhydride, whereas 5-methyl group was inert to such an attack. © 1971, The Pharmaceutical Society of Japan. All rights reserved.